Withdrawal from Fioricet in those who are dependent and/ or addicted to the medication can begin in as little as 16 hours after the last dose. An individual can experience a range of withdrawal symptoms, ranging from mild discomfort, to intense pain and discomfort. Especially if Fioricet was combined with other substances such as alcohol or other prescription painkillers, withdrawal symptoms can be particularly difficult to deal with. The best way to detox from Fioricet is to be steadily weaned-off of the medication. This can be accomplished effectively at a medically managed detoxification facility, which is highly advised to be utilized by an individual seeking help for dependence or addiction to Fioricet. By gradually reducing the amount of medication needed, many of the following symptoms can be avoided or experienced only at minimal intensity.