Due to its chemical structure nandrolone is weakly exposed to aromatase (only 20% of the aromatizing activity of testosterone). However, not estrogenic effects are its main concern: nandrolone has a potent progestogenic activity (20% of progesterone). While binding to progestogenic pituitary receptors nandrolone causes increased production of prolactin, which in effect is very similar to estrogen: its effect presents in reducing testosterone production, increasing fat mass and in gynecomastia. To prevent these side effects prolactin inhibitors (cabergoline) shall always be at hand when on nandrolones cycle.
Edema/ increased fluid retention may occur if Nandrolone Decanoate is used concurrently with corticosteroids. This may be more pronounced with corticosteroids like fludrocortisone which have greater mineral Corti steroid activity.
In a majority of cases, androgens are usually necessary to induce a growth response in a human growth hormone therapy in children, but its levels should be checked and maintained because an overdose can accelerate the maturation of the epiphyses and termination of growth.
This list does not include all the possible drug interactions, so you should make sure that you communicate to your physician before you begin or stop administering this medicine.